Read more about this disease, some with Classification – Types – Signs and symptoms – Genetics – Pathophysiology – Diagnosis – Screening – Prevention – Treatment and management – Cures and much more, some including pictures and video when available.
Carpal tunnel syndrome (CTS), or median neuropathy at the wrist, is a medical condition in which the median nerve is compressed at the wrist, leading to paresthesias, numbness and muscle weakness in the hand. The diagnosis of CTS is often misapplied to patients who have activity-related arm pain.
Most cases of CTS are idiopathic (without known cause), genetic factors determine most of the risk, and the role of arm use and other environmental factors is disputed.
Night symptoms and waking at night–the hallmark of this illness–can be managed effectively with night-time wrist splinting in most patients. The role of medications, including corticosteroid injection into the carpal canal, is unclear. Surgery to cut the transverse carpal ligament is effective at relieving symptoms and preventing ongoing nerve damage, but established nerve dysfunction in the form of static (constant) numbness, atrophy, or weakness are usually permanent and do not respond predictably to surgery.
Although the condition was first noted in medical literature in the early 20th century, the first use of the term “carpal tunnel syndrome” was in 1939.[1] The pathology was identified by physician Dr. George S. Phalen of the Cleveland Clinic after working with a group of patients in the 1950s and 1960s.[1] CTS became widely known among the general public in the 1990s because of the rapid expansion of office jobs.[2]
The median nerve passes through the carpal tunnel, a canal in the wrist that is surrounded by bone on three sides, and a transverse carpal ligament on the fourth. Nine tendons—the flexor tendons of the hand—pass through this canal.[3] The median nerve can be compressed by a decrease in the size of the canal, an increase in the size of the contents (such as the swelling of lubrication tissue around the flexor tendons), or both. Simply bending the wrist at 90 degrees will decrease the size of the canal.
Compression of the median nerve as it runs deep to the transverse carpal ligament (TCL) causes wasting of the thenar eminence, weakness of the flexor pollicis brevis, adductor pollicis, opponens pollicis, abductor pollicis brevis, as well as sensory loss in the distribution of the median nerve distal to the transverse carpal ligament, sparing the superficial sensory branch given that its branch point is normally proximal to the TCL and travels superficially thus avoiding compression.
Many people that have carpal tunnel syndrome have gradually increasing symptoms over time. The first symptoms of CTS may appear when sleeping and typically include numbness and paresthesia (a burning and tingling sensation) in the thumb, index, and middle fingers, although some patients may experience symptoms in the palm as well.[3] These symptoms appear at night because people tend to bend their wrists when they sleep, which further compresses the carpal tunnel.
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